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Together with the University of Oxford in 2014, he co-founded Nightstar Therapeutics in order to expand retinal gene therapy towards worldwide approval for patients with retinal diseases. He has been a recipient of the ARVO Camras Award for Translational Research, the RP Fighting Blindness Scientist of the Year Award, the American Academy of Ophthalmology Achievement Award, the Royal College of Ophthalmologists Keeler Medal and the Macular Society Clinical Service of the Year award. He is also a Fellow of the Royal College of Ophthalmologists, Fellow and former King James IV Professor of Surgery at the Royal College of Surgeons of Edinburgh, Fellow of the American College of Surgeons, Fellow of the Academy of Medical Sciences, Bodley Fellow of Merton College Oxford and Civilian Consultant Advisor to the Royal Navy.
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Robert MacLaren is Professor of Ophthalmology at the University of Oxford, Consultant Ophthalmologist at the Oxford Eye Hospital, Honorary Professor of Ophthalmology at the UCL Institute of Ophthalmology, Honorary Consultant Vitreoretinal Surgeon at Moorfields Eye Hospital and an NIHR Senior Investigator. Professor of Ophthalmology at the University of Oxford, Consultant Ophthalmologist at the Oxford Eye Hospital, Honorary Professor of Ophthalmology at the UCL Institute of Ophthalmology, Honorary Consultant Vitreoretinal Surgeon at Moorfields Eye Hospital and an NIHR Senior Investigator
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Her research is focussed on disease mechanisms, complement therapeutics (target validation, indication validation, drug discovery) and complement biomarkers (diagnosis, stratification). She is currently based at Newcastle University and the National Renal Complement Therapeutics Centre (NRCTC, Royal Victoria Infirmary, Newcastle). Subsequent dissection of functional consequences of common AMD-linked polymorphisms led to the concept of the ‘complotype’ -the influence of complement genetic makeup on inflammation & infection. With collaborators in Madrid, she was the first to characterise ‘gain-of-function’ mutations in the complement activating proteins, C3 and factor B, explaining their association with renal disease. She has a keen interest in structure-function relationships in complement activators and regulators with a particular focus in the mechanisms underlying complement dysregulation and disease. She has been studying complement for more than 30 years with experience in both academia and Pharma. Professor of Molecular Immunology, Newcastle University, UKĬlaire Harris is Professor of Molecular Immunology at Newcastle University. Adamis is also on the board of directors of RD Funds, the venture arm of the Foundation Fighting Blindness. With the introduction of anti-VEGF drugs, the rates of legal blindness from neovascular AMD and diabetic eye disease have decreased by half globally. Adamis co-founded Eyetech Pharmaceuticals, which developed and obtained FDA approval for the first anti-VEGF medicine in ophthalmology.
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He completed his ophthalmology residency at the University of Michigan and his fellowship at Harvard. Adamis received his medical degree with honours from the University of Chicago Pritzker School of Medicine. Food and Drug Administration (FDA) across various indications. These development programmes led to 24 approvals by the U.S. He has guided the development of 20 medicines in global clinical trials involving more than 25,000 patients. Adamis is best known for co-discovering the central role of vascular endothelial growth factor (VEGF) in ocular vascular disease, including age-related macular degeneration (AMD) and diabetic retinopathy. Anthony (Tony) Adamis joined the board of directors of Gyroscope Therapeutics in December 2021.